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Neuromodulation · TMS · Ampa One

A full course of TMS,
in a single day.

My primary TMS system is Ampa One. Through its One-Day TMS Program, treatment that traditionally takes weeks of daily visits can be delivered in a single day — inside a complete, concierge psychiatric relationship.

Ampa Primary TMS System

Ampa One is FDA-cleared for the treatment of treatment-resistant depression, by prescription only.

See if you're a candidate → Watch patient stories

What is TMS?

Transcranial Magnetic Stimulation (TMS) is a safe, non-invasive therapy that uses magnetic pulses to stimulate areas of the brain involved in mood regulation. Unlike medications, no chemicals circulate throughout your body — instead, TMS helps interrupt the patterns of brain activity linked to depression. The FDA first cleared TMS in 2008 for treatment-resistant depression. It is not electroconvulsive ("shock") therapy and does not require anesthesia.

The Ampa One system

I've chosen Ampa One as my primary TMS system. It's an FDA-cleared TMS system featuring a camera-enabled coil designed to support precise coil positioning and repeatable session setup — the kind of consistency that matters when you're delivering a full course of care in a focused window.

The One-Day TMS Program

A standard course of TMS usually involves daily visits, five days a week, for several weeks — about 36 sessions in total. Traditional schedules like that don't work for everyone.

The One-Day TMS Program compresses that course: patients receive multiple TMS sessions across a single, structured day, with sessions spaced out and rest periods in between, and return home the same day. Each session delivers brief (about three-minute) intermittent theta-burst stimulation (iTBS) to the mood-regulating circuits of the left prefrontal cortex. For the right candidate, it's a more accessible path — and a far more discreet one. Schedules vary by patient and are determined during your evaluation.

Why this fits my practice

Most TMS is delivered in a high-volume clinic, as a standalone procedure. I do it differently: the One-Day TMS Program sits inside a complete psychiatric relationship — physician-led, integrated with therapy, metabolic care, and the lifestyle work that helps gains hold. Your clinician may also recommend brief preparation steps intended to support neuroplasticity during treatment.

The Evidence

What the research shows.

The single-day, neuroplasticity-enhanced iTBS regimen has been studied in peer-reviewed research — with outcomes that rival, and in comparison may exceed, traditional TMS.

87.5%
Responded at six weeks
ONE-D case series (n=32), HDRS-17
71.2%
In remission at six weeks
ONE-D case series (n=32), HDRS-17
49%
Single-day remission vs. 25%
for a matched 36-day course (PHQ-9)

In the ONE-D open-label case series (Vaughn et al., 2025), 32 adults with depression completed a single-day course of 600-pulse iTBS with neuroplasticity-enhancing augmentation; 87.5% responded and 71.2% achieved remission at six weeks (HDRS-17), with no serious adverse events. In a separate propensity-matched comparison (Berlow et al., 2026), single-day TMS achieved PHQ-9 remission in 49% of patients versus 25% for a matched 36-day course, and anxiety remission (GAD-7) in 62% versus 33%. These are early findings from small, open-label and retrospective samples; the studied regimen includes pharmacologic augmentation, randomized controlled trials are still needed, and individual results may vary.

Vaughn et al. (2025) · ONE-D, Transcranial Magnetic Stimulation ↗ Berlow et al. (2026) · Single-Day vs Once-Daily TMS (preprint) ↗
Why People Choose TMS

A different kind of treatment.

Real-world clinical data find that the majority of patients respond to TMS. Individual results may vary.

i.

Natural

Stimulates brain circuits involved in emotional regulation and resilience.

ii.

Medication-free

Avoids many of the ongoing side effects associated with antidepressants.

iii.

Well-tolerated

Side effects are usually mild — for example, temporary scalp discomfort or headache.

iv.

Proven

TMS has been studied since 1985, with more than 80 randomized trials in depression.

Patient Stories

What one day can change.

Stories from people who have been through the One-Day TMS Program, shared by Ampa. They reflect personal experiences — not a promised outcome.

The moment TMS changed her life

Featured Story
The One-Day experience
Making the treatment decision
Talking about results
Life after the program

Patient stories are individual experiences shared with permission and provided by Ampa. They are not typical of every patient, do not predict your results, and are not a substitute for medical advice. Individual results may vary.

“This has been a life-saver. I didn't know life could be like this.”

— A TMS patient · individual experience, shared by Ampa
The Frontier

Beyond depression: where the science is heading.

TMS is FDA-cleared for treatment-resistant depression. But the research frontier is widening fast — and my practice actively follows, and is investigating, these emerging protocols as options for the future.

Investigational

Anxiety

In the single-day studies, anxiety symptoms improved markedly alongside depression — with remission in roughly 62% of single-day patients in one comparison. Accelerated, augmented protocols are an active area of study for anxiety in its own right.

Investigational

OCD

TMS is an established option for OCD, and neuroplasticity-augmented protocols have shown greater symptom reductions in research — a promising direction for accelerated, single-day OCD care as the evidence matures.

Investigational

Addiction

Stimulating the prefrontal circuits involved in craving and compulsion is one of the most active frontiers in addiction medicine — a natural extension of my fellowship training in addiction psychiatry, and a direction I'm watching closely.

These applications are investigational and, where applicable, off-label — they are not FDA-cleared uses of the Ampa One system, which is cleared for treatment-resistant depression. Availability depends on clinical judgment and the current state of the evidence, and is discussed individually.

How We Work

Three ways to use neuromodulation.

Every path is physician-led, individualized, and woven into your broader care — never delivered as a standalone procedure.

Flagship

One-Day TMS Program

A course of TMS on the Ampa One system, delivered across a single structured day — the most accessible, discreet path for the right candidate.

ForTreatment-resistant depression
TimeOne day
StatusFDA-cleared system
Established

Standard TMS course

The traditional schedule — daily visits, five days a week, for several weeks (about 36 sessions). The same evidence-based foundation, at a measured pace.

ForTreatment-resistant depression
TimeSeveral weeks
StatusFDA-cleared
Off-label · Investigational

Brain Optimization

A separate, physician-led offering for high-performers — neuromodulation used selectively to support focus, mental clarity, stress resilience, and recovery from burnout.

ForPerformance, resilience
TimeIndividualized
StatusOff-label

Brain Optimization is a distinct, off-label and investigational use of neuromodulation — it is not part of, or implied by, the FDA clearance of the Ampa One system for treatment-resistant depression. It is offered selectively, after thorough evaluation, with realistic and individualized goals, and only when clinically appropriate.

Your Treatment Day

What the One-Day TMS Program looks like.

01

Calibration

Your care team measures your motor threshold to set a safe, effective, personalized level of stimulation.

02

Sessions through the day

About every 30 minutes you receive a brief stimulation session targeting mood-related regions — comfortable, awake, no anesthesia.

03

Rest between

You spend the breaks relaxing, reading, or walking — whatever feels most comfortable for you.

04

Home the same day

By evening you're done and can go home. There are no activity restrictions.

The Appasani Difference

A technology is only as good as the hands it's in.

Most TMS is delivered in a vacuum — a machine, a technician, a series of appointments. Here, it sits inside a complete psychiatric relationship: physician-led, integrated with therapy and metabolic care, and held to the standard of a concierge practice. The brain changes; the life around it changes too.

Ampa My Primary TMS System
Request a Consultation → About Dr. Appasani
Questions

Good to know.

What is Ampa One? +
Ampa One is an FDA-cleared transcranial magnetic stimulation (TMS) system, cleared for the treatment of treatment-resistant depression by prescription only. It features a camera-enabled coil designed to support precise coil positioning and repeatable session setup.
What is the One-Day TMS Program? +
Traditional TMS involves daily clinic visits over several weeks. To make treatment more accessible, the One-Day TMS Program delivers multiple TMS sessions in a single day — sessions are spaced throughout the day with rest periods in between, and patients return home the same day. Schedules vary by patient and are determined by your clinician.
How effective is TMS? +
Real-world clinical data find that the majority of patients respond to TMS. For the single-day, neuroplasticity-enhanced regimen specifically, the ONE-D open-label case series (n=32) reported 87.5% response and 71.2% remission at six weeks, and a propensity-matched comparison found single-day remission of 49% versus 25% for a 36-day course. These are early findings from small, open-label or retrospective samples; the effects may not be permanent, some patients benefit from maintenance, and individual results may vary. See the research ↗
Is it safe, and what are the side effects? +
TMS is generally well tolerated. Side effects are usually mild and temporary — for example, headache, scalp discomfort, or brief facial muscle activation during treatment. The most serious possible side effect, a seizure, is very rare (about 0.003% per session). TMS is not appropriate for patients with certain implanted metallic or electronic devices near the head; your clinician reviews safety screening and contraindications before treatment.
Can TMS be used for brain optimization or performance? +
Beyond the FDA-cleared treatment of treatment-resistant depression, neuromodulation is sometimes used off-label to support focus, cognitive clarity, stress resilience, and recovery from burnout. These applications are off-label and investigational — not FDA-cleared — and are offered selectively, under close physician supervision, only after thorough evaluation with realistic, individualized goals.
Does insurance cover it? +
The practice is out-of-network, which preserves the time, privacy, and depth concierge care requires. Many patients receive partial reimbursement through out-of-network benefits, and a detailed superbill is provided. Coverage for accelerated and off-label options varies; fees are discussed during consultation.

Important Information

This page is for general educational purposes and does not constitute medical advice or establish a physician–patient relationship. Ampa One is FDA-cleared for the treatment of treatment-resistant depression, by prescription only. TMS is not appropriate for everyone; candidacy is determined during a clinical evaluation, including safety screening and review of contraindications.

Real-world clinical data find that the majority of patients respond to TMS; the effects may not be permanent, some patients require additional or maintenance treatment, and individual results may vary. Quantitative figures cited on this page come from the ONE-D open-label case series (Vaughn et al., 2025) and a propensity-matched comparison (Berlow et al., 2026) of a single-day, pharmacologically augmented iTBS regimen; these are early findings from small, open-label or retrospective samples, randomized controlled trials are still needed, and outcomes are not guaranteed. TMS is generally well tolerated — side effects are usually mild and temporary (such as headache or scalp discomfort), and the most serious possible side effect, a seizure, is very rare (about 0.003% per session).

Patient stories are individual experiences shared with permission and provided by Ampa; they are not representative of every patient. Brain Optimization and other performance-oriented uses of neuromodulation, and applications for anxiety, OCD, and addiction, are investigational and/or off-label, are not FDA-cleared, and are distinct from the Ampa One system's cleared indication for treatment-resistant depression.

If you are experiencing a mental health emergency, or if mood worsens or suicidal thoughts emerge during treatment, contact your clinician immediately, call or text 988, or call 911.

One day could change the conversation.

A confidential first consultation, with no obligation. Let's find out whether the One-Day TMS Program is right for you.

Request a Consultation → (424) 432-0452